Nov 14, 2011 · Because it penetrates the central nervous system in therapeutic concentrations and appears to reduce HIV replication in the central nervous system, LPV/r may benefit subjects who receive a diagnosis of or are at risk for HIV–associated neurocognitive disorders.Cited by: 50.
However, this disease still kills several million people each year. Though the reason for therapeutic failure is multi-factorial, an important concern is the treatment and control of HIV within the central nervous system (CNS). Due to the restricted entry of anti-HIV drugs, the Cited by: 214.
Invasion of the CNS by HIV occurs soon after initial infection. Currently available assays indicate that HIV does not infect neurons. Rather, infection of accessory cell types, such as microglia.
HIV and AIDS is an? acquired immune deficiency syndrome. PO med, penetrates blood brain barrier, can use during pregnancy, CNS reactions. NNRTIs (Non-Nucleoside Reverse Transcriptase Inhibitor) Efavirenz (Sustiva) binds to the active center of reverse transcriptase and cause direct inhibition of RT activity, affects P-450 system (increase.